Selected Publications
Kevin A. Guttenplan, Maxwell I, Santos E, Borchardt L, Manzo E, Abalde-Atristain L, Kim R, Freeman M. GPCR signaling gates astrocyte responsiveness to neurotransmitters and control of neuronal activity. Science.
Kevin A. Guttenplan, Maya K. Weigel, Priya Prakash, Prageeth R. Wijewardhane, Philip Hasel, Uriel Rufen-Blanchette, Alexandra E. Münch, Jacob A. Blum, Jonathan Fine, Mikaela Neal, Kimberley D. Bruce, Aaron D. Gitler, Gaurav Chopra, Shane A. Liddelow, Ben A. Barres. Neurotoxic reactive astrocytes induce cell death via saturated lipids. 2021. Nature
Kevin A. Guttenplan, Maya Weigel, Julien Couthois, Drew Adler, Shane Liddelow*, Aaron Gitler*, Ben Barres*. Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model. 2020. Nature Communications.
All Publications
Primary Research
Kevin A. Guttenplan, Maxwell I, Santos E, Borchardt L, Manzo E, Abalde-Atristain L, Kim R, Freeman M. GPCR signaling gates astrocyte responsiveness to neurotransmitters and control of neuronal activity. Science. 2025; 388:763–768. doi: 10.1126/science.adq5729
Ellen R. Bowen1, Phillip DiGiacomo1, Hannah P. Fraser1, Kevin A. Guttenplan1, Benjamin A. H. Smith, Marlene L. Heberling, Laura Vidano, Nigam Shah, Mehrdad Shamloo, Jennifer L. Wilson & Kevin V. Grimes. Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease. 2023. Discover Mental Health. doi: 10.1007/s44192-023-00050-5 (1authors contributed equally)
Kevin A. Guttenplan, Maya K. Weigel, Priya Prakash, Prageeth R. Wijewardhane, Philip Hasel, Uriel Rufen-Blanchette, Alexandra E. Münch, Jacob A. Blum, Jonathan Fine, Mikaela Neal, Kimberley D. Bruce, Aaron D. Gitler, Gaurav Chopra, Shane A. Liddelow, Ben A. Barres. Neurotoxic reactive astrocytes induce cell death via saturated lipids. 2021. Nature. 10.1038/s41586-021-03960-y
Kevin A. Guttenplan, Maya Weigel, Julien Couthois, Drew Adler, Shane Liddelow*, Aaron Gitler*, Ben Barres*. Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model. 2020. Nature Communications. doi: 10.1038/s41467-020-17514-9
Kevin A. Guttenplan, Benjamin Stafford, Rana El-Danaf, Drew Adler, Alex Münch, Maya Weigel, Andrew Huberman, Shane Liddelow. Neurotoxic reactive astrocytes drive neuronal death following retinal injury. 2020. Cell Reports. doi: 10.1016/j.celrep.2020.107776
Priya Prakash, Krupal P. Jethava, Nils Korte, Pablo Izquierdo, Emilia Favuzzi, Indigo Rose, Kevin A. Guttenplan, Sayan Dutta, Christopher Jean-Rochet, Gordon Fishell, Shane Liddelow, David Attwell, Gaurav Chopra. Real-time glial uptake of pH-fluorogenic human amyloid-beta in live animals. 2021. Chemical Science. doi: 10.1039/D1SC03486C
Jacob A. Blum, Sandy Klemm, Jennifer L. Shadrach, Kevin A. Guttenplan, Lisa Nakayama, Arwa Kathiria, Phuong T. Hoang, Olivia Gautier, Julia A. Kaltschmidt, William J. Greenleaf, & Aaron D. Gitler. Single-cell transcriptomic analysis of the adult mouse spinal cord. 2021. NatureNeuroscience. doi: 10.1038/s41593-020-00795-0
Lilianne Barbar, Tanya Jain, Matthew Zimmer, Ilya Kruglikov, Jessica S Sadick, Minghui Wang, Kriti Kalpana, Indigo V L Rose, Suzanne R Burstein, Tomasz Rusielewicz, Madhura Nijsure, Kevin A. Guttenplan, Angelique di Domenico, Gist Croft, Bin Zhang, Hiroko Nobuta, Jean M Hébert, Shane A Liddelow, Valentina Fossati. 2020. CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes. 2020. Neuron. doi: 10.1016/j.neuron.2020.05.014
Shane A. Liddelow, Kevin A. Guttenplan, Laura E. Clarke, Frederick C. Bennett, Christopher J. Bohlen, Lucas Schirmer, Mariko L. Bennett, Alexandra E. Münch, Won-Suk Chung, Todd C. Peterson, Daniel K. Wilton, Arnaud Frouin, Brooke A. Napier, Nikhil Panicker, Manoj Kumar, Marion S. Buckwalter, David H. Rowitch, Valina L. Dawson, Ted M. Dawson, Beth Stevens & Ben A. Barres. Neurotoxic reactive astrocytes are induced by activated microglia. 2017. Nature. doi:10.1038/nature21029
Reviews, Commentary, and Essays
Madison T. Hupp, Erin N. Santos, Dongeun Heo, Cody L. Call, and Kevin A. Guttenplan. Vesicle Fusion in Oligodendrocyte Maturation and Myelination. 2024. Journal of Neuroscience. doi: 10.1523/JNEUROSCI.2203-23.2024
Kevin A Guttenplan. Why do neurons die? 2022. Science. doi: 10.1126/science.ade2129
Kevin A Guttenplan & Aaron Gitler. Why you always in a mood? Pumpin’ polyP, actin’ brand new. 2022. Neuron. doi: https://doi.org/10.1016/j.neuron.2022.04.003
Kevin A Guttenplan & Shane A Liddelow. Astrocytes and microglia: Models and tools. 2018. Journal of Experimental Medicine. doi: 10.1084/jem.20180200
Kevin A. Guttenplan, Jacob Blum, & Mariko Bennett. A Role for Microglia in Retinal Development. 2018. Journal of Neuroscience. doi: 10.1523/JNEUROSCI.1813-18.2018
Kevin A Guttenplan & Shane A Liddelow. Play It Again, SAM: Macrophages Control Peripheral Fat Metabolism. 2018. Trends in Immunology. doi:10.1016/j.it.2017.12.004
Link for all published work: https://orcid.org/0000-0003-4242-4349